The Role of Combination Treatment of Aspirin and Prednisone in Women with Idiopathic Recurrent Miscarriage

Objective: To investigate whether the combination treatment of prednisone during the first trimester of pregnancy plus low dose aspirin all through pregnancy is cable of reducing the risk of miscarriage and improving live birth rates in patients with idiopathic recurrent miscarriage. Material and Methods: 144 Patients were enrolled in the trial, attending outpatient clinics of Kasr El-Aini, Mahmoud Hospital and Misr International Hospital during the period from February 2008 to January 2011. 78 patients gave informed consent and started treatment, 66 patients refused and comprised the control group. Treatment was consisting of prednisone 20mg/d for the first trimester and tapered gradually plus aspirin 81mg for 38 weeks gestation. Treatment started preconceptionally. Results: The demographic variables of women under trial, did not differ with respect to age, BMI and No. of previous abortions. live birth rates for the treated women and the control were 78.2%, 50.0% respectively. Women who were treated had a 28.2% higher live birth rate than control. Conclusion: A combination treatment of prednisone and aspirin results in higher live birth rates compared with no treatment in women with idiopathic recurrent miscarriage.